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Research Laboratories of Douglas D. Ross, MD, PhD

• Research and Academic Activities:
  • Cancer Drug Resistance, Molecular Pharmacology
  • Translational Clinical Trials
  • Xenobiotic Transporter Proteins
  • Mechanism of Action of Antineoplastic Drugs
  • Palliative Care Education
    
• Recent Research and Academic Accomplishments:
  • Described and documented the function the novel drug resistance transporter Breast Cancer Resistance Protein (BCRP)... genbank AF098951
  • Developed and incorporated required training in palliative and end-of-life care into the curriculum of the University of Maryland School of Medicine
    
• Grant Support:
  • Merit Review Grant from Department of Veterans Affairs, "Mechanisms of Resistance in Human Cancers" (Douglas D. Ross, PI)
  • NCI R25-CA66940, "Hospice Educational Program for the School of Medicine" (Douglas D. Ross, PI)
  • TRI support from NCI for translational studies on protocol GCC0447/NCI6829 "Phase I study of vorinostat in combination with cytosine arabinoside and etoposide for patients with relapsed and/or refractory acute leukemias, myelodysplasias, and myeloproliferative disorders."
    
• Collaborators at the UMGCC:
  • Takeo Nakanishi, Bret Hassel PhD, Ivana Gojo, MD, Ming Tan, PhD, Hongbin Fang, PhD, Stuart Martin, PhD, Angelika Burger, PhD, Maria Baer, MD, Edward Sausville, MD, PhD, Ken Bauer PhD, The Biopolymer Core Laboratory (Nick Ambulos, PhD)
    
• Laboratory Personnel:
  • GRADUATE STUDENT: Karthika Natarajan
  • RESEARCH ASSOCIATE: Takeo Nakanishi, PhD 
  • Students: David Carlton
    
• Selected Recent Publications:
  Laboratory Research:
  Fandy TE, Ross DD, Gore SD, Srivastava RK. Flavopiridol synergizes TRAIL cytotoxicity by downregulation of FLIPL. Cancer Chemother Pharmacol. 2007 Aug;60(3):313-9. Epub 2006 Dec 23.

  Nakanishi T, Bailey-Dell KJ, Hassel BA, Shiozawa K, Sullivan DM, Turner J, Ross DD.  Novel 5' untranslated region variants of BCRP mRNA are differentially expressed in drug-selected cancer cells and in normal human tissues: implications for drug resistance, tissue-specific expression, and alternative promoter usage. Cancer Res. 2006 May 15;66(10):5007-11.

  Nakanishi T, Shiozawa K, Hassel BA, Ross DD. Complex interaction of BCRP/ABCG2 and imatinib in BCR-ABL-expressing cells: BCRP-mediated resistance to imatinib is attenuated by imatinib-induced reduction of BCRP expression. Blood. 2006 Jul 15;108(2):678-84. Epub 2006 Mar 16.

  Gupta A, Dai Y, Vethanayagam RR, Hebert MF, Thummel KE, Unadkat JD, Ross DD, Mao Q. Cyclosporin A, tacrolimus and sirolimus are potent inhibitors of the human breast cancer resistance protein (ABCG2) and reverse resistance to mitoxantrone and topotecan. Cancer Chemother Pharmacol. 2006 Sep;58(3):374-83. Epub 2006 Jan 11.

  Lee DI, Sumbilla C, Lee M, Natesavelalar C, Klein MG, Ross DD, Inesi G, Hussain A. Mechanisms of resistance and adaptation to thapsigargin in androgen-independent prostate cancer PC3 and DU145 cells. Arch Biochem Biophys. 2007 Aug 1;464(1):19-27. Epub 2007 Apr 16.

  Shankar S, Singh TR, Fandy TE, Luetrakul T, Ross DD, Srivastava RK. Interactive effects of histone deacetylase inhibitors and TRAIL on apoptosis in human leukemia cells: involvement of both death receptor and mitochondrial pathways. Int J Mol Med. 2005 Dec;16(6):1125-38.

  Garimella TS, Ross DD, Eiseman JL, Mondick JT, Joseph E, Nakanishi T, Bates SE, Bauer KS. Plasma pharmacokinetics and tissue distribution of the breast cancer resistance protein (BCRP/ABCG2) inhibitor fumitremorgin C in SCID mice bearing T8 tumors. Cancer Chemother Pharmacol. 2005 Feb;55(2):101-9. Epub 2004 Oct 1.

  Suvannasankha A, Minderman H, O'Loughlin KL, Nakanishi T, Ford LA, Greco WR, Wetzler M, Ross DD, Baer MR.  Breast cancer resistance protein (BCRP/MXR/ABCG2) in adult acute lymphoblastic leukaemia: frequent expression and possible correlation with shorter disease-free survival. Br J Haematol. 2004 Nov;127(4):392-8.

  Ross DD, Doyle LA. Mining our ABCs: pharmacogenomic approach for evaluating transporter function in cancer drug resistance. Cancer Cell. 2004 Aug;6(2):105-7.

  Suvannasankha A, Minderman H, O'Loughlin KL, Nakanishi T, Greco WR, Ross DD, Baer MR. Breast cancer resistance protein (BCRP/MXR/ABCG2) in acute myeloid leukemia: discordance between expression and function. Leukemia. 2004 Jul;18(7):1252-7.

  Garimella TS, Ross DD, Bauer KS.  Liquid chromatography method for the quantitation of the breast cancer resistance protein ABCG2 inhibitor fumitremorgin C and its chemical analogues in mouse plasma and tissues. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Aug 5;807(2):203-8.

  Krishnamurthy P, Ross DD, Nakanishi T, Bailey-Dell K, Zhou S, Mercer KE, Sarkadi B, Sorrentino BP, Schuetz JD. The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. J Biol Chem. 2004 Jun 4;279(23):24218-25. Epub 2004 Mar 24.

  Ee PL, Kamalakaran S, Tonetti D, He X, Ross DD, Beck WT. Identification of a novel estrogen response element in the breast cancer resistance protein (ABCG2) gene. Cancer Res. 2004 Feb 15;64(4):1247-51.

   Palliative Care Education:
  Ross DD, Shpritz D, Hull MM, Goloubeva O. Long-term evaluation of required coursework in palliative and end-of-life care for medical students. J Palliat Med. 2005 Oct;8(5):962-74.

  Ross DD, Shpritz D, Alexander CS, Carter K, Edelman MJ, Friedley N, Hemani A, Keay TJ, Roy SC, Silverman H, Tasker DJ, Timmel D, Schwartz J, Wolfsthal SD. Development of required postgraduate palliative care training for internal medicine residents and medical oncology fellows. J Cancer Educ. 2004 Summer;19(2):81-7.

  Seligman, P.A., Dignon, C., Ross D.D., Steen, P.D., Abrahm, J.L., Boston, P.H., Ferris, F., Foley, J., Nelson-Martin, P., O’Mara, A.M., Von Gunten, C.F., Weissman, D.E., and the AACE Multi-institutional Palliative Cancer Education Section (D.D. Ross, Chair). “Development of a teaching module for quality-of-life assessment of terminal patients”, Journal of Cancer Education, 1999, 14: 129-131.

  Ross D.D., Keay T., Timmel D., Alexander C., Dignon C., O'Mara A., O'Brien W III.  “Required training in hospice and palliative care at the University of Maryland School of Medicine”, Journal of Cancer Education, 1999, 14:132-136.

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